Estradiol Benzoate + Progesterone Injection
- Packing: 1 Ml Ampoule, 1 ml PFS
- Available Strength : 2.5 + 12.5 Mg
Description
Product Description: Estradiol Benzoate + Progesterone Injection is a combination medication containing estradiol benzoate, a synthetic estrogen, and progesterone, a hormone. It is formulated for intramuscular injection and is used for hormone replacement therapy.
Indications and Usage: Estradiol Benzoate + Progesterone Injection is indicated for the treatment of menopausal symptoms such as hot flashes, vaginal dryness, and mood swings. It is also used to prevent osteoporosis and to regulate menstrual cycles in women with hormonal imbalances.
Dosage and Administration: The dosage of Estradiol Benzoate + Progesterone Injection depends on the individual patient's hormonal needs and response to therapy. It is typically administered intramuscularly once every 1 to 4 weeks. The dose may vary depending on the severity of symptoms and the patient's age and medical history.
Dosage Forms and Strengths: Estradiol Benzoate + Progesterone Injection is available as a clear, colorless solution in vials or ampules. Each milliliter of solution contains a specified amount of estradiol benzoate and progesterone, typically ranging from 1 mg to 10 mg of estradiol benzoate and 20 mg to 100 mg of progesterone per mL.
Contraindications: Estradiol Benzoate + Progesterone Injection is contraindicated in patients with a history of breast cancer, endometrial cancer, or other hormone-sensitive malignancies. It should not be used in pregnant women or individuals with a known hypersensitivity to any of the components of the formulation.
Warnings and Precautions: Before initiating therapy with Estradiol Benzoate + Progesterone Injection, healthcare providers should evaluate patients for the presence of cardiovascular disease, thromboembolic disorders, liver dysfunction, and other conditions that may be exacerbated by hormone therapy. Patients should be monitored regularly for signs of estrogen-related adverse effects, including breast tenderness, fluid retention, and changes in mood.
Adverse Reactions/Side Effects: Common adverse reactions associated with Estradiol Benzoate + Progesterone Injection include nausea, headache, breast pain, breakthrough bleeding, and changes in menstrual flow. Other potential side effects may include weight gain, bloating, mood swings, and allergic reactions.
Drug Interactions: Estradiol Benzoate + Progesterone Injection may interact with other medications, including anticoagulants, corticosteroids, anticonvulsants, and certain herbal supplements. Healthcare providers should carefully monitor patients receiving concomitant therapy for potential drug interactions.
Use In Specific Populations Description: Estradiol Benzoate + Progesterone Injection is not recommended for use in pregnant women due to the risk of fetal harm. It should be used with caution in women with a history of breast or endometrial cancer, as estrogen therapy may increase the risk of tumor recurrence.
How Supplied/Storage and Handling: Estradiol Benzoate + Progesterone Injection is supplied as a solution in vials or ampules. It should be stored at controlled room temperature, protected from light and moisture. Unused portions should be discarded according to local regulations for biohazardous waste disposal.